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Carcinogenic properties

A retrospective mortality study of Yusho victims and an informal survey of Yu-Cheng deaths provides inconclusive evidence of liver cancer.

An intermediate duration study in mice showed no skin neoplastic activity following dermal application of 2,3,4,7,8-pentaCDF or 1,2,3,4,7,8-hexaCDF alone, although these congeners as well as 2,3,7,8-tetraCDF promoted development of mouse skin neoplasms. These congeners also promoted development of liver tumours in rats following subcutaneous injection, providing further evidence of tumour promotion by PCDFs. Results of a 2-year carcinogenicity study in which 2,3,4,7,8-pentaCDF or 1,2,3,4,7,8-hexaCDF were administered to rats by 1 single or 4 weekly subcutaneous injections are inconclusive due to small numbers of tested animals.

 

 


Structure formula of 2,3,7,8-Tetrachlorodibenzo-furan