No human studies are available on for any exposure route. Similarly, no studies are available for animals exposed via the inhalation route, and negligible information is available for animals exposed via the dermal route. Several studies report a decrease in postnatal survival for offspring of dogs, rats, and mice exposed to aldrin by the oral route, although many of these studies are flawed.
Adverse developmental effects have been observed following maternal oral exposure to aldrin, and an acuteduration oral MRL for aldrin was derived based on the decrease in pup body weight and increased electroconvulsive shock threshold of pups observed in this study. Teratogenic effectts have been observed in only a limited number of the studies performed to assess developmental toxicity.
There were only two studies on in vivo exposure of humans to aldrin. Both were limited due to concomitant exposure to other pesticides and inconclusive route and dose of exposure. Studies investigating the in vitro genotoxic effects of dieldrin provide no conclusive evidence for genotoxic effects, particularly for direct action on the DNA molecule.
No human data regarding reproductive effects of aldrin were located. Studies in laboratory animals exposed orally to aldrin present conflicting data on the ability of these agents to cause decreased fertility.
No studies in animals were found regarding reproductive effects of exposure by the inhalation or dermal routes. Animal studies performed using intraperitoneal injection of aldrin demonstrate adverse effects on male reproductive capacity.